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March 24, 2011.

Lucy was prescribed with adrenaline 0.1% (1:1000, 1 mg/mL) solution 5 and ibuprofen 100 mg orally, tds prn because of the health problem she had. The two drugs are somehow related in action but to some extent there are some differences. Adrenaline is a drug that is given to a patient because it enhances the blood pressure, increases blood glucose, and it increases air entry through stimulation of the cardiac activity. Adrenaline also reduces the propensity of allergic reactions by curbing inflammatory responses hence is a critical drug in the treatment of allergic and anaphylactic reactions, in this case the allergy that Lucy has towards pineapples. Adrenaline contains elements that are nonselective agonist of all adrenergic receptors even to receptors such as α1, α2, β1, β2, and β3 (Bower). The adrenaline’s binding to these receptors will trigger a number of metabolic changes like inhibiting the secretion of insulin by the pancreas, increased secretion of ACTH in the pituitary gland. These effects combined will lead to an increase blood glucose and fatty acids hence providing substrates for the energy production within cells throughout the body of the patient (Yoke et al., 2007).

Ibuprofen is crucial in treatment of asthmatic cases because of its anti- inflammatory properties, this drugs acts as vasodilator because it dilates the blood vessels especially the coronary arteries so as to ease the circulation of blood and operations of the lungs which are the main problems inflicting Lucy because of asthma. In action ibuprofen is a no steroidal anti-inflammatory drugs and it works by inhibiting the enzyme known as cyclooxygenase (COX) that is responsible of converting arachidonic acid to compound called prostaglandin H2 (PGH2) (Yoke et al., 2007). This inhibition will make other enzymes other than cyclooxygenase to convert PGH2, to several other prostaglandins that are crucial in relieving fever, pain and inflammation.


Bower, John. Ibuprofen: uses and side effects. University of Bristol, School of Chemistry.

Available at

Yoke Hwee et al. (2007). ‘Severe Anaphylactic Reaction to Ibuprofen in a Child with Recurrent

Urticaria’. Official journal of the American academy of pediatrics. Vol. 120 No. 3 September 2007, pp. e742-e744 (doi:10.1542/peds.2006-2634). Available at